Beau’s Lines Resulting from Taxane Chemotherapy

Central corneal opacification resulting from recent chemotherapy in corneal donors.

PURPOSE Ocular surface disease following penetrating keratoplasty has been shown to increase patient morbidity and adversely affect graft survival. Five cases of dense central subepithelial opacification were noted in keratoplasty patients who received tissue from donors who had chemotherapy prior to death. Cancer-related deaths account for approximately 20% of the cornea donor pool. The purpos...

Esophageal Stricture Resulting from Systemic Chemotherapy for Solid Malignancy

Although dysphagia in patients treated for malignancy is usually related to reflux esophagitis, infectious esophagitis, malignant infiltration, or as a complication of radiation therapy, acute esophageal stricture resulting from chemotherapy is very rare. Only 2 prior cases have been described in the treatment of an adult patient with malignancy. We present a unique case of isolated chemotherap...

Neutropenic enterocolitis in breast cancer patient after taxane-containing chemotherapy.

Neutropenic enterocolitis or typhlitis (from the Greek typhlon, meaning caecum) is defined as a necrotizing colitis with inflammation of the cecum and surrounding tissues. Although this condition occurs primarily in severely myelosuppressed and immunosuppressed patients with leukemia, it may also occur in those with other advanced malignancies receiving myelosuppressive chemotherapy. It has bee...

Targeting Mechanisms of Resistance to Taxane-Based Chemotherapy

TITLE : Androgen receptor splice variants and resistance to taxane chemotherapy

Docetaxel-based chemotherapy is established as a first-line treatment and standard of care for patients with metastatic castration-resistant prostate cancer. However, half of the patients do not respond to treatment and those do respond eventually become refractory. A better understanding of the resistance mechanisms to taxane chemotherapy is both urgent and clinical significant, as taxanes (do...